Case studies present realistic, complex, and contextually rich situations, often involve a dilemma, conflict, or problem and are used in problem-based learning. They give students practice identifying the parameters of a problem, recognizing and articulating positions, evaluating courses of action, and considering different points of view. Cases can be used not only to teach scientific concepts and content, but also to develop skills and opportunities for critical thinking. The brain is hard-wired for processing stories and case studies can be engaging, can facilitate learning, and can leave a lasting impression of how to use the process of deduction. This presentation will allow participants to engage in an interactive discourse to solve complex clinical breastfeeding case studies such as insufficient milk in a mother with spina bifida occulta, an infant with multiple sign and symptoms culminating in a vitamin B12 deficiency, a mother with insufficient milk production due to a polymorphism in cellular zinc transport. Participants will use their knowledge of anatomy, physiology, and lactation acting as detectives to discover the etiology of selected breastfeeding problems and develop a plan of care for each scenario.