Did you know that a mother who breastfeeds her child is more likely to “match” as an organ donor than a mother who does not breastfeed her child? How does that happen? The answer may lie in the Maternal-Newborn Microbiome, AKA “The Oro-boobular” axis. The scientific world is exploding with excitement over the discovery of the microbiome. While it appears clear that suckling infant’s intestinal microbiome communicates with the mother’s lactocyte and perhaps beyond, little is known about the effects of this communication in practical terms. This presentation will review what is known and attempt to explain what it means, both now and in the future.