A variety of losses and types of grief are common in the perinatal time period. Some of these losses are specifically related to the reproductive and perinatal experience and some just happen to occur during pregnancy or after birth. Perinatal care providers who understand the diverse experience of loss and grief are better able to provide compassionate and effective care for the families they seek to serve. This presentation provides an overview of loss and grief, including the difference between bereavement, grief, and mourning; ambiguous loss; disenfranchised grief; prolonged grief; chronic sorrow; and depression. It also describes skills—such as companioning, screening, and referral—that are part of providing grief-sensitive care to expectant and new parents who are coping with loss and grief.